Publications

Article - Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Bioorg Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6.

June 2021

Article - An MXD1-derived repressor peptide identifies noncoding mediators of MYC- driven cell proliferation.

Raffeiner P, Hart JR, Garcia-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6571-6579. doi: 10.1073/pnas.1921786117. Epub 2020 Mar 10.

March 2020

Article - PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9.

Bell CM, Raffeiner P, Hart JR, Vogt PK. Cancers (Basel). 2019 Oct 24;11(11). pii: cancers11111634. doi: 10.3390/cancers11111634.

October 2019

Article - Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD.

Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutskov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmuller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC. Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17.

September 2018

Article - Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets.

Ito Y, Hart JR, Vogt PK. Expert Opin Ther Targets. 2018 Oct;22(10):869-877. doi: 10.1080/14728222.2018.1522302. Epub 2018 Sep 24.

September 2018

Article - Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins.

Guo L, Yang W, Huang Q, Qiang J, Hart JR, Wang W, Hu J, Zhu J, Liu N, Zhang Y. Cell Chem Biol. 2018 Nov 15;25(11):1380-1388.e4. doi: 10.1016/j.chembiol.2018.08.006. Epub 2018 Aug 30.

September 2018

Article - Synthetic molecules for disruption of the MYC protein-protein interface.

Jacob NT, Miranda PO, Shirey RJ, Gautam R, Zhou B, de Orbe Izquierdo ME, Hixon MS, Hart JR, Ueno L, Vogt PK, Janda KD. Bioorg Med Chem. 2018 Aug 7;26(14):4234-4239. doi: 10.1016/j.bmc.2018.07.019. Epub 2018 Jul 11.

July 2018

Article - Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85alpha and p85beta.

Ito Y, Vogt PK, Hart JR. Oncotarget. 2017 Aug 3;8(34):55863-55876. doi: 10.18632/oncotarget.19866. eCollection 2017 Aug 22.

September 2017

Article - tsRNA signatures in cancer.

Balatti V, Nigita G, Veneziano D, Drusco A, Stein GS, Messier TL, Farina NH, Lian JB, Tomasello L, Liu CG, Palamarchuk A, Hart JR, Bell C, Carosi M, Pescarmona E, Perracchio L, Diodoro M, Russo A, Antenucci A, Visca P, Ciardi A, Harris CC, Vogt PK, Pekarsky Y, Croce CM. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8071-8076. doi: 10.1073/pnas.1706908114. Epub 2017 Jul 10.

July 2017

Article - A butterfly effect in cancer.

Vogt PK, Hart JR, Yates JR 3rd. Mol Cell Oncol. 2015 Apr 14;3(1):e1029063. doi: 10.1080/23723556.2015.1029063. eCollection 2016 Jan.

June 2016

Article - A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Athuluri-Divakar SK, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP. Cell. 2016 Apr 21;165(3):643-55. doi: 10.1016/j.cell.2016.03.045.

April 2016

Article - MINCR is not a MYC-induced lncRNA.

Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E496-7. doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25.

January 2016

Article - Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex.

Saayman SM, Lazar DC, Scott TA, Hart JR, Takahashi M, Burnett JC, Planelles V, Morris KV, Weinberg MS. Mol Ther. 2016 Mar;24(3):488-98. doi: 10.1038/mt.2015.202. Epub 2015 Nov 19.

November 2015

Article - ProteinInferencer: Confident protein identification and multiple experiment comparison for large scale proteomics projects.

Zhang Y, Xu T, Shan B, Hart J, Aslanian A, Han X, Zong N, Li H, Choi H, Wang D, Acharya L, Du L, Vogt PK, Ping P, Yates JR 3rd. J Proteomics. 2015 Nov 3;129:25-32. doi: 10.1016/j.jprot.2015.07.006. Epub 2015 Jul 18.

July 2015

Article - A brave new MYC-amplified world.

Weinberg MS, Hart JR, Vogt PK. Aging (Albany NY). 2015 Jul;7(7):459-60. doi: 10.18632/aging.100777.

July 2015

Article - Stopping MYC in its tracks.

Stefan E, Hart JR, Bister K. Aging (Albany NY). 2015 Jul;7(7):463-4. doi: 10.18632/aging.100780.

July 2015

Article - Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR.

Roberts TC, Hart JR, Kaikkonen MU, Weinberg MS, Vogt PK, Morris KV. Nat Protoc. 2015 Aug;10(8):1198-211. doi: 10.1038/nprot.2015.076. Epub 2015 Jul 16.

July 2015

Article - MYCNOS functions as an antisense RNA regulating MYCN.

Vadie N, Saayman S, Lenox A, Ackley A, Clemson M, Burdach J, Hart J, Vogt PK, Morris KV. RNA Biol. 2015;12(8):893-9. doi: 10.1080/15476286.2015.1063773.

July 2015

Article - MYC regulates the non-coding transcriptome.

Hart JR, Roberts TC, Weinberg MS, Morris KV, Vogt PK. Oncotarget. 2014 Dec 30;5(24):12543-54. doi: 10.18632/oncotarget.3033.

January 2015

Article - The butterfly effect in cancer: a single base mutation can remodel the cell.

Hart JR, Zhang Y, Liao L, Ueno L, Du L, Jonkers M, Yates JR 3rd, Vogt PK. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1131-6. doi: 10.1073/pnas.1424012112. Epub 2015 Jan 12.

January 2015

Article - Oncogenic activity of the regulatory subunit p85beta of phosphatidylinositol 3-kinase (PI3K).

Ito Y, Hart JR, Ueno L, Vogt PK. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16826-9. doi: 10.1073/pnas.1420281111. Epub 2014 Nov 10.

November 2014

Article - In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Raffeiner P, Rock R, Schraffl A, Hartl M, Hart JR, Janda KD, Vogt PK, Stefan E, Bister K. Oncotarget. 2014 Oct 15;5(19):8869-78. doi: 10.18632/oncotarget.2588.

October 2014

Article - Inhibitor of MYC identified in a Krohnke pyridine library.

Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61. doi: 10.1073/pnas.1319488111. Epub 2014 Aug 11.

August 2014

Article - MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.

April 2014

Article - PI3K and STAT3: a new alliance.

Vogt PK, Hart JR. Cancer Discov. 2011 Nov;1(6):481-6. doi: 10.1158/2159-8290.CD-11-0218.

February 2012

Article - Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110alpha of phosphoinositide-3-kinase.

Sun M, Hart JR, Hillmann P, Gymnopoulos M, Vogt PK. Cell Cycle. 2011 Nov 1;10(21):3731-9. doi: 10.4161/cc.10.21.17920. Epub 2011 Nov 1.

November 2011

Article - Essential role of Stat3 in PI3K-induced oncogenic transformation.

Hart JR, Liao L, Yates JR 3rd, Vogt PK. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13247-52. doi: 10.1073/pnas.1110486108. Epub 2011 Jul 25.

July 2011

Article - Phosphorylation of AKT: a mutational analysis.

Hart JR, Vogt PK. Oncotarget. 2011 Jun;2(6):467-76. doi: 10.18632/oncotarget.293.

June 2011

Article - Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K).

Hart JR, Liao L, Ueno L, Yates JR 3rd, Vogt PK. Cell Cycle. 2011 Mar 15;10(6):971-6. doi: 10.4161/cc.10.6.15077. Epub 2011 Mar 15.

February 2011

Article - Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Sun M, Hillmann P, Hofmann BT, Hart JR, Vogt PK. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52. doi: 10.1073/pnas.1009652107. Epub 2010 Aug 16.

August 2010

Article - Phosphatidylinositol 3-kinase: the oncoprotein.

Vogt PK, Hart JR, Gymnopoulos M, Jiang H, Kang S, Bader AG, Zhao L, Denley A. Curr Top Microbiol Immunol. 2010;347:79-104. doi: 10.1007/82_2010_80.

June 2010

Article - Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.

Dannemann N, Hart JR, Ueno L, Vogt PK. Int J Cancer. 2010 Jul 1;127(1):239-44. doi: 10.1002/ijc.25012.

October 2009

Article - Akt demoted in glioblastoma.

Vogt PK, Hart JR. Sci Signal. 2009 Apr 21;2(67):pe26. doi: 10.1126/scisignal.267pe26.

April 2009

Article - PI 3-kinase and cancer: changing accents.

Vogt PK, Gymnopoulos M, Hart JR. Curr Opin Genet Dev. 2009 Feb;19(1):12-7. doi: 10.1016/j.gde.2008.11.011.

February 2009

Article - Biochemical and biological characterization of tumor-associated mutations of p110alpha.

Denley A, Gymnopoulos M, Hart JR, Jiang H, Zhao L, Vogt PK. Methods Enzymol. 2008;438:291-305. doi: 10.1016/S0076-6879(07)38020-8.

April 2008

Article - DNA mismatch-specific targeting and hypersensitivity of mismatch-repair- deficient cells to bulky rhodium(III) intercalators.

Hart JR, Glebov O, Ernst RJ, Kirsch IR, Barton JK. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15359-63. doi: 10.1073/pnas.0607576103. Epub 2006 Oct 9.

October 2006

Article - Single-nucleotide polymorphism discovery by targeted DNA photocleavage.

Hart JR, Johnson MD, Barton JK. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14040-4. doi: 10.1073/pnas.0406169101. Epub 2004 Sep 21.

September 2004

Article - [Ru(bpy)2(L)]Cl2: luminescent metal complexes that bind DNA base mismatches.

Ruba E, Hart JR, Barton JK. Inorg Chem. 2004 Jul 26;43(15):4570-8. doi: 10.1021/ic0499291.

July 2004

Article - A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition.

Junicke H, Hart JR, Kisko J, Glebov O, Kirsch IR, Barton JK. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3737-42. doi: 10.1073/pnas.0537194100. Epub 2003 Feb 27.

March 2003
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