Jonathan Hart

San Diego, CA ¬∑ jonat-remove-[email protected]

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I am a scientist at The Scripps Research Institute in La Jolla, California. I study MYC and PI 3-kinase in the context of cancer as a member of the Vogt laboratory. My primary role is providing computational and bioinformatics support to the group.



  • Cancer
  • Intrinsically Disordered Proteins
  • Genomics
  • Cryo-EM
  • lncRNAs
  • MYC
  • PI3K
  • Eukaryotic Cell Culture
  • Cloning
  • Western Blots
  • Protein Purification
  • Assay Development
Scientific Software
Computer Architecture
  • IP Networking
  • DNS
  • Firewalls
  • Load Balancing
  • Microservices
Languages, Operating Systems & Tools
  • R
  • Python
  • C++
  • git
  • linux
  • bash
Containers & Cloud

Article - Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Bioorg Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6.

June 2021

Article - An MXD1-derived repressor peptide identifies noncoding mediators of MYC- driven cell proliferation.

Raffeiner P, Hart JR, Garcia-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6571-6579. doi: 10.1073/pnas.1921786117. Epub 2020 Mar 10.

March 2020

Article - The butterfly effect in cancer: a single base mutation can remodel the cell.

Hart JR, Zhang Y, Liao L, Ueno L, Du L, Jonkers M, Yates JR 3rd, Vogt PK. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1131-6. doi: 10.1073/pnas.1424012112. Epub 2015 Jan 12.

January 2015

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Staff Scientist

October 2012 - Present

Postdoctoral Scholar

August 2006 - October 2012


2000 - 2006
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