A butterfly effect in cancer.

Link to full Article

Vogt PK, Hart JR, Yates JR 3rd

Mol Cell Oncol. 2015 Apr 14;3(1):e1029063. doi: 10.1080/23723556.2015.1029063. eCollection 2016 Jan.

A point mutation in PIK3CA, the gene encoding the alpha isoform of class I phosphatidylinositol 3-kinase, induces extensive remodeling of the transcriptome and proteome, resulting in a gene signature that specifically resembles that of the basal subtype, but not other types, of breast cancer.

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