Content tagged with PIK3CA

• Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
• Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.
• Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.
• The butterfly effect in cancer: a single base mutation can remodel the cell.