Jonathan Hart
Rockville, MD ·
jonat[email protected]
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Currently, I am a data scientist with the U.S. Digital Corps working at the Department of State. Data to inform diplomacy. Previously, bioinformatics and cell biology at Scripps Research studying MYC and PI 3-kinase.
Certifications
Socialization
Skills
Interests
- Storytelling with Data
- Human-Centered Design
- Kaizen Process Improvement
- Agile Data Science
Languages, Operating Systems & Tools
- R
- Python
- SQL
- C++
- git
- linux
- bash
Containers & Cloud
Scientific Interests
- Cancer
- Intrinsically Disordered Proteins
- Genomics
- Cryo-EM
- lncRNAs
- MYC
- PI3K
Biology Techniques
- Eukaryotic Cell Culture
- Cloning
- Western Blots
- Protein Purification
- Assay Development
Scientific Software
Article - Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2215621119. doi: 10.1073/pnas.2215621119. Epub 2022 Nov 7.
November 2022
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Article - Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2210769119. doi: 10.1073/pnas.2210769119. Epub 2022 Sep 12.
September 2022
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Article - Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.
Liu X, Yang S, Hart JR, Xu Y, Zou X, Zhang H, Zhou Q, Xia T, Zhang Y, Yang D, Wang MW, Vogt PK. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2109327118. doi: 10.1073/pnas.2109327118.
November 2021
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Article - Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.
Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Bioorg Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6.
June 2021
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Article - An MXD1-derived repressor peptide identifies noncoding mediators of MYC- driven cell proliferation.
Raffeiner P, Hart JR, Garcia-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6571-6579. doi: 10.1073/pnas.1921786117. Epub 2020 Mar 10.
March 2020
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Article - The butterfly effect in cancer: a single base mutation can remodel the cell.
Hart JR, Zhang Y, Liao L, Ueno L, Du L, Jonkers M, Yates JR 3rd, Vogt PK. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1131-6. doi: 10.1073/pnas.1424012112. Epub 2015 Jan 12.
January 2015
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See all Publications for more examples!
Experience
USDC Fellow - Data Science
July 2022 - Present
Staff Scientist
October 2012 - July 2022
Postdoctoral Scholar
August 2006 - October 2012
Education
2020 - 2022
2000 - 2006
1997 - 1999
Resources: DC Public Library
The DC Public Library is more than books. In addition to the normal books, periodicals, and research help, the library provides classes, meeting rooms, co-working space, and a wealth of online resources. The online resources were surprising in their depth.
DC is a large city and a great library is expected. The stacks were well stocked and organized in a reasonable way. The design was interesting as the shelves are all 3 feet tall giving the library a great open feeling.
December 26, 2022